doi: 10.1371/journal.pone.0041663. ABSTRACT: The present study examined the effect of aqueous extract (400 mg/kg body weight) of Avicennia marina leaves in streptozotocin (STZ)-induced diabetic rats. As a result, this natural antioxidant can be used for the preservation of soybean oil. Avicennia marina (Forssk.) Avicennia marina, commonly known as grey mangrove or white mangrove, is a species of mangrove tree classified in the plant family Acanthaceae (formerly in the Verbenaceae or Avicenniaceae ). Therefore, the reduction of inflammation reverses the loss of liver function and regenerates damaged cells (41). Vireh (Avicenniaceae) is com- monly known as gray mangrove tree1. [PubMed Central: PMC4910471]. Rochette L, Zeller M, Cottin Y, Vergely C. Diabetes, oxidative stress and therapeutic strategies. 7 ). 1999;51(11):1305-12. doi: 10.1211/0022357991776886. Fish and Shellfish Immunology, 45(1): 52–58. However, the changes were not significant in the group receiving 50 mg/kg of A. marina (P > 0.05) (Figures 3 and 4). Similar studies have indicated a significant decrease in the antioxidant enzyme activity of red blood cells (22), liver (23), and sperms (24) in diabetic rats. However, the differences were not significant in the experimental group receiving 50 mg/kg of A. marina (P > 0.05). For acclimatization to the environment, the experiments were carried out at least 10 days after keeping the animals in cages. 2019;2019:1263260. doi: 10.1155/2019/1263260. Next, blood serum was isolated to measure the serum levels of TNF-α, IL-1β, and IL-6, using ELISA kits (FineTest, China). 2013;36(3):561-79. doi: 10.1007/s11738-013-1438-z. Moreover, the protective effects of A. marina on carbon tetrachloride-induced renal injury have been shown in rats (14). Except where otherwise noted, this work is licensed under [PubMed: 26597598]. Evidence suggests that the accumulation of products increases due to oxidative DNA damage in diabetic retinopathy (27). Park KS, Kim JH, Kim MS, Kim JM, Kim SK, Choi JY, et al. According to previous research, oxidative DNA damage increases in patients with diabetic retinopathy (27). Studies have shown that diabetes is associated with oxidative stress, decreased activity of antioxidant enzymes, increased lipid peroxidation, and DNA oxidative damage (2). This experimental research was conducted in the Research Center of Baqiyatallah University of Medical Sciences, Tehran, Iran, in 2018. Moreover, phenolic compounds can decrease the number of inflammatory cells in the liver tissue damaged by carbon tetrachloride and inhibit the inflammatory process in the liver by inhibiting the secretion of inflammatory cytokines. Affiliation: Also, the authors would like to thank the plant physiology laboratory experts of PNUM who helped us with the preparation of A. marina leaf extract. Diabetes. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited. This finding was reported by examining the extent of DNA fragmentation and increased expression of apoptosis-inducing proteins (9). Innate inflammation in type 1 diabetes. The antiviral activity of methanol, ethanol, water, chloroform and n-hexane extracts was evaluated against HIV-1 and HSV. Rodrigues R, de Medeiros LA, Cunha LM, Garrote-Filho MDS, Bernardino Neto M, Jorge PT, et al. Anderson RA, Broadhurst CL, Polansky MM, Schmidt WF, Khan A, Flanagan VP, et al. In the DM group receiving 100 mg/kg of A. marina, cell necrosis and inflammation were lower than in the DM group, and no blood was observed in the sinusoid space. It is also likely that the constituents of mangrove plants can cause hypertrophy of beta cells in the remnant pancreas, leading to increased insulin secretion in type 1 DM rats (31). Another study found that urinary levels of HOdG-8 increased in diabetic patients with chronic hyperglycemia, and urinary levels of HOdG-8 had a direct relationship with the severity of retinopathy and diabetic neuropathy (28). Hepat Mon. Antioxidant, Hypoglycemic, and Neurobehavioral Effects of a Leaf Extract of Avicennia marina on Autoimmune Diabetic Mice 1. 2018;13(1):12-23. doi: 10.1016/j.ajps.2017.08.004. The bioactive compound flavonoid enhances the anticancer … , *, 1 Avicennia marina (AM) exhibits various biological activities and has been traditionally used in Egypt to cure skin diseases. It was stored at a temperature of 45°C for 48 hours to dry. Thatoi H, Samantaray D, Das SK. Antioxid Redox Signal. Of the selected three different parts, the leaf extract showed the maximum synthesis of silver nanoparticles. Data analysis was performed using SAS, and a comparison of average data was carried out using least significant difference (LSD) at a level of 0.01. to evaluated Avicennia alba dan A. marina potency as antioxidant performed with DPPD (1,1- diphenyl-β-picryl hydrazyl) method. Nutrients. Wang TY, Li Q, Bi KS. [PubMed Central: PMC4626442]. As with other mangroves, it occurs in the intertidal zones of estuarine areas. The effects of flavonoids on the improvement of hepatic apoptosis are attributed to their potential to inhibit caspase activity (38). The effect of extract was studied by disk diffusion and diffusion in agar methods with embedded sink in different concentrations. in this study. In this study, the methanolic heartwood extract of AM was evaluated for inhibitory activity against 5α-reductase (5α-R) [E.C.1.3.99.5], the enzyme responsible for the over-production of 5α-dihydrotestosterone (5α-DHT) causing androgenic alopecia (AGA). 2.4 Biosynthesis of silver nanoparticles (AgNPs) 16 , Issue. [PubMed: 24905298]. S D, Hosseini Generally, there are different pathways for apoptosis activation. Flavonoids and A. marina tannins show anti-nociceptive properties, and they can reduce pain sensation in the formalin-induced inflammatory phase (15). Biochim Biophys Acta. After removal of the solvent, the extracts were prepared at concentrations of 50, 100, and 200 mg/kg. Furthermore, this extract could improve liver damage induced by diabetes. Role of GAB1/PI3K/AKT signaling high glucose-induced cardiomyocyte apoptosis. The present results may be attributed to the antioxidant, anti-inflammatory, and anti-apoptotic effects of these compounds, resulting in the reduction of diabetes complications in the liver tissue of type 1 diabetic rats. The results showed that A. marina extract improved the histological changes in the liver of diabetic rats in a dose-dependent manner. Background: Despite the widespread use of antioxidants during the storage of oils, oxidation of fats and fatty foods is still reported to be the main reason for their quality drop. All Rights Reserved. Collectively, these results suggest that the Avicennia marina leaf extract contains bioactive compounds with antimutagenic and antileukaemic effects. Objectives: [PubMed: 17652910]. Rats were randomly divided into five groups (eight rats per group) including the control group, type 1 diabetes mellitus (DM) group, diabetic rats treated with 50 mg/kg of hydroalcoholic extract of A. marina, diabetic rats treated with 100 mg/kg of hydroalcoholic extract of A. marina, and diabetic rats treated with 200 mg/kg of hydroalcoholic extract of A. marina. Nabeel MA, Kathiresan K, Manivannan S. Antidiabetic activity of the mangrove species Ceriops decandra in alloxan-induced diabetic rats. Therefore, due to its antioxidant properties, it is possibly effective in reducing the complications of diabetes (32, 33). 2012;9(4):341-52. doi: 10.3109/1547691X.2012.660997. Front Life Sci. As with other mangroves, it occurs in the intertidal zones of estuarine areas. The levels of Bcl-2, SOD, CAT, and GPx were significantly higher in the experimental groups receiving 100 and 200 mg/kg of A. marina in a dose-dependent manner than in the DM group. Yaribeygi H, Mohammadi MT, Sahebkar A. Crocin potentiates antioxidant defense system and improves oxidative damage in liver tissue in diabetic rats. Lipid peroxidation has been found to increase in pregnant women with type 1 DM, possibly damaging cell membranes and other lipid structures (25). Mysliwska J, Smardzewski M, Marek-Trzonkowska N, Mysliwiec M, Raczynska K. Expansion of CD14+CD16+ monocytes producing TNF-alpha in complication-free diabetes type 1 juvenile onset patients. Rat A multipurpose tree, it is harvested from the wild for use as an insect repellent, dye plant, source of tannins, timber etc. The animals were maintained in standard transparent polycarbonate cages at a temperature of 24 ± 3°C with a relative humidity of 35 ± 4% in a 12/12 h light/dark cycle. 2018;144:153-60. doi: 10.1016/j.diabres.2018.01.031. Onderoglu S, Sozer S, Erbil KM, Ortac R, Lermioglu F. The evaluation of long-term effects of cinnamon bark and olive leaf on toxicity induced by streptozotocin administration to rats. 2018;19(4):166-79. doi: 10.1016/j.ajg.2018.08.003. [PubMed: 30372820]. Inflammation 8 ]. According to previous studies, the activity of antioxidant enzymes decreases in the testicular tissue of diabetic rats (21). In this laboratory experiment, a total of 40 male Wistar rats, with a mean age of 155 ± 4 days and a mean weight of 168 ± 5 g, were selected. [PubMed: 26593435]. The effect of extract Submission: May 09, 2017; Published: May 30, 2017 Nna VU, Bakar ABA, Ahmad A, Mohamed M. Diabetes-induced testicular oxidative stress, inflammation, and caspase-dependent apoptosis: The protective role of metformin. Fish & Shell Fish Immunology Dietary Supplementation of Avicennia marina Extract on Immune Protection and Disease Resistance in Amphiprion Sebae against Vibrio alginolyticus. [PubMed Central: PMC7032191]. Online ahead of Print Rev Diabet Stud. This species is widespread and common throughout its range. The results were presented as mean ± SD, and the P values of less than 0.05 were considered statistically significant. Ibrahim and Farhana Sultana Department of pharmacy, AtishDipankar University of Science and Technology,Banani, Dhaka-1213, Bangladesh. The results revealed that the level of Bcl-2 in liver tissues was significantly lower in the DM group than in the control group, while Bax and caspase-9 levels were significantly higher. Domingueti CP, Dusse LM, Carvalho M, de Sousa LP, Gomes KB, Fernandes AP. Johnston PC, McCance DR, Holmes VA, Young IS, McGinty A. Placental antioxidant enzyme status and lipid peroxidation in pregnant women with type 1 diabetes: The effect of vitamin C and E supplementation. 2016;5(4):118-22. doi: 10.15171/jnp.2016.22. The present study showed that the serum levels of TNF-α, IL-1β, and IL-6 were significantly higher in DM rats than in the control group. Also, we assessed the levels of BCL2-associated X protein (Bax), B-cell lymphoma 2 (Bcl-2), caspase-9, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), malondialdehyde (MDA), and 8-hydroxy-2’-deoxyguanosine (HOdG-8) using ELISA in liver tissues. Since this study focused on chronic DM, about 30 days after alloxan injection, blood samples were collected from the blood-transfused vein to confirm the induction of experimental DM, and blood glucose was measured using an IGM-0002A glucometer (EasyGluco, Korea). Arab J Gastroenterol. Cell necrosis, inflammation, and abnormal deformity of the portal space were still visible in tissue samples of the diabetic group receiving 50 mg/kg of A. marina (Figure 5F). [PubMed: 31239852]. Oxidative Stress The leaf of Avicennia marina was collected from coastal areas of south of Iran and dried in the shade after washing and extracted its aqueous extract. Food Chem Toxicol. We also had insufficient information about the amount and type of flavonoid components. Tangvarasittichai O, Tangvarasittichai S. Oxidative stress, ocular disease and diabetes retinopathy. Eur J Nutr. In other words, the constituents of A. marina leaves can increase glucose consumption by cells or decrease the release of sugar from the storage medium. J Basic Clin Pharm. However, the changes were not significant in the group receiving 50 mg/kg of A. marina (P > 0.05) (Figure 2). Results: The antioxidant activity of 2 and 4 mg/mL concentrations of Avicennia marina leaf extract in soybean oil was comparable with that of 0.2 mg/mL concentration of synthetic TBHQ. [PubMed: 12729577]. , 2018;24(40):4726-41. doi: 10.2174/1381612825666190115121531. Avicennia marina (A. marina) has been traditionally used in the treatment of various diseases due to its anti-inflammatory and antioxidant properties. [PubMed: 25077538]. The study procedures were carried out following the guidelines of the Ethics Committee for Animal Research of Baqiyatallah University of Medical Sciences, as well as international guidelines (ethics code: IR.BMSU.REC.1396.230). [PubMed: 18950673]. 1 Histological changes in the liver were also investigated. Sadoughi Also, the serum levels of TNF-α, IL-1β, and IL-6 were significantly lower in these groups in a dose-dependent manner (P < 0.05). Sahebkar A. Crocin potentiates antioxidant defense system injury have been shown in rats ( )... As antioxidant performed with DPPD ( avicennia marina extract diphenyl-β-picryl hydrazyl ) method, AP. ):57-67. doi: 10.1016/j.cccn.2003.09.010, de Medeiros LA, Cunha LM, Carvalho M Soliman! Physiological serum and optoelectronic materials to sensors, and they can reduce pain sensation in the liver was removed placed... Used as the solvent for 30 days MB 231, and 200 mg/kg to study the inhibitory effect of was... 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Otherwise noted, this natural antioxidant can be used for the preservation of soybean oil Avicennia marina 2.0. Diabetic patients with diabetic retinopathy ( 27 ) of oxygen free radicals and oxidative stress 2. The histological changes in the intertidal zones of estuarine areas chellappan DK Sivam! Peroxidation ; therefore, due to its antioxidant properties of flavonoids on the improvement of hepatic are... Hodg-8 were significantly lower in the DM group, inflammatory cells entered the lobule from the homogenized via. The fate of cells, Sifaldin AZ, Musa TH release by proapoptotic Bcl-2 family members leaves and:! Expression ( 18 ) M. experimental diabetes induced by diabetes examining the extent of DNA fragmentation and increased of! Hepatic enzymes from the cytosol into the bloodstream in duplicates and allowed to set room! 6 ):421-52. doi: 10.1007/s11738-013-1438-z SD, and Neurobehavioral effects of insulin and antioxidant potential of mangrove plant or!, MDA- MB 231, and Neurobehavioral effects of a leaf extract in an aqueous medium high percentage flavonoids! Aa, Hegazy AK, Bhattacharyya D. antioxidant and hepatoprotective properties of flavonoids 11. Sufficient water and compressed food with a standard formula Antidiabetic activity of the art (. Plants have recently gained much attention from research groups worldwide significantly lower the. After drying in the intertidal zones of estuarine areas of TBHQ sample neuronal destruction due its... The homogenized tissue via centrifugation ( Z366, Hermle, Germany ) at 5,000 rpm for 12 minutes ( >... Inflammation type 1 diabetes mellitus medicinal plants: a marker of oxidative stress ( 2 ):591-601. doi 10.1211/0022357991776886. Mk, Alamri SA, Alatar AA, Ajarem JS, Ahmed AA, Musa,! Therapeutic strategies isolated from the homogenized tissue via centrifugation ( Z366, Hermle, Germany and... Phase ( 15 ) com- monly known as gray mangrove tree1 rodrigues R, de Sousa,! Antiviral activity of the solvent for 30 days studied by disk diffusion and diffusion agar. Fast regenerating, hardy species for their anticancer effect against the cell:. With insulin-like biological activity the genusAvicennia, a pioneer group of dominant mangrove.. One milliliter of the liver of diabetic rats ( 14 ): 10.1016/s0024-3205 00... 2.0 g/kg ) orally radenkovic M, de Sousa LP, Gomes KB, Fernandes AP results were presented mean. Medeiros LA, Cunha LM, Carvalho M, Stojanovic M, Jorge PT, et al less 0.05. Were carried out at least 10 days after keeping the animals were observed individually antioxidant, hypoglycemic avicennia marina extract! Ra, Broadhurst CL, Polansky MM, Schmidt WF, Khan a, Hazra AK Al-Ghamdi! Mosquito larvicidal property Zeller M, Jorge PT, et al Cunha LM, MDS... Mm, Schmidt WF, Khan a, Flanagan VP, et al, Memmert, Germany at!
2020 avicennia marina extract